• br Acknowledgments br Introduction Non steroidal anti inflam

  2021-10-23

  

  Acknowledgments Introduction Non-steroidal anti-inflammatory drugs (NSAIDs) are a common treatment for a number of disease states involving an inflammatory reaction. This group of drugs mediate their anti-inflammatory effects mainly by inhibition of cyclooxygenase (COX), an enzyme of prime imp

• Mitochondria are also involved in other modalities of progra

  2021-10-22

  

  Mitochondria are also involved in other modalities of programmed cell death, particularly apoptosis. Intriguingly, the roles of mitochondria in apoptosis and ferroptosis are fundamentally different. In mitochondria-mediated apoptosis, the mitochondrion serves as a reservoir, storing apoptosis-regula

• The H R antagonist cimetidine Tagamet became the first billi

  2021-10-22

  

  The H2R antagonist cimetidine (Tagamet™) became the first billion-dollar drug in the 1980s for the treatment of peptic ulcer disease. Other H2R antagonists include ranitidine, famotidine, nizatidine, and zolantidine, the latter showing good BBB penetration with a steady-state brain/blood ratio of 1.

• A number of studies have reported

  2021-10-22

  

  A number of studies have reported that lncRNA may function as sponge to interact with miRNAs at posttranscriptional level, thereby regulating miRNA targeted genes (Tang et al., 2015, Han et al., 2015). For example, lncRNA Malat1 induces autophagy by regulating ULK2 via sponging miR-26b (Li et al., 2

• Treatment and control for IBD are targeted to identify and

  2021-10-22

  

  Treatment and control for IBD are targeted to identify and eliminate the cause if possible, decrease intestinal inflammation, reduce diarrhea and vomiting, improve appetite, and promote weight gain. Methods include dietary manipulation with or without concurrent medical therapy such as corticosteroi

• br Material and methods br Results br Discussion In this

  2021-10-22

  

  Material and methods Results Discussion In this paper, an HCV molecular epidemiological study was conducted in DU sentinel surveillance sites in 20 prefecture-level cities across Guangdong Province, and the different subtype distributions between IDU and NIDU were compared. Owing to the lac

• br Materials and methods br Results br Discussion ENU

  2021-10-22

  

  Materials and methods Results Discussion ENU mutagenesis is a powerful approach to identify novel genes or itk inhibitor to dissect the molecular basis of mammalian immune system (Siggs, 2014). T cells are critical components in the host defense against pathogens, and their activity has to

• Cerulenin receptor The neuronal glycine receptor HSOR

  2021-10-22

  

  The neuronal glycine receptor/3α-HSOR/allopregnanolone pathway may also be extended to the central nervous effects of gelsemine and koumine in brain. 3α-HSOR is expressed in certain brain regions in rats and humans, such as the limbic system including hypothalamus, hippocampus and amygdala, in addit

• Several studies have found decreased astroglial and neuronal

  2021-10-22

  

  Several studies have found decreased astroglial and neuronal cell numbers and alpha amanitin damage after OP exposure. Neuronal loss and brain lesions increase proportionally to the severity and duration of OP-induced seizures (Albuquerque et al., 2006, Carpentier et al., 2000, Gullapalli et al., 20

• br Acknowledgements Supported by the grant from National Nat

  2021-10-22

  

  Acknowledgements Supported by the grant from National Natural Science Funds of China (81371262). I would like to express my heartfelt gratitude to Professor Yonghua Zhu, who help language editing. Introduction Glucocorticoids are steroid hormones secreted from the adrenal glands in response t

• br Materials and methods br

  2021-10-22

  

  Materials and methods Chemical synthesis Declaration of interest Acknowledgements This research was supported by a grant from the National Institute for General Medicine to K.W.M. (GM 58448) and by the Department of Anesthesia, Critical Care & Pain Medicine at Massachusetts General Hospi

• Compounds were tested for GPR activity in a

  2021-10-21

  

  Compounds , were tested for GPR40 activity in a functional assay monitoring calcium flux in CHO W123 sale transiently transfected with human GPR40 gene. As shown in , compound was found to be a nanomolar GPR40 agonist, while compound was much less potent than . To explore the structure activity r

• Factor Xa FXa has emerged as

  2021-10-21

  

  Factor Xa (FXa) has emerged as a particularly promising target for the development of effective anticoagulant drugs because FXa acts at the convergence point of the extrinsic and intrinsic coagulation pathways. It efficiently catalyzes the conversion of prothrombin to thrombin with one molecule of F

• Several studies have also shown that

  2021-10-21

  

  Several studies have also shown that HK2 may be an important downstream Apatinib sale of the PI3K/AKT/mTOR signaling pathway and may contribute to the development of cancer [15]. In our previous study, we found AKT2 expression was positively correlated with HK2 expression in primary colon cancer sp

• Several layers of regulation for

  2021-10-21

  

  Several layers of regulation for this canonical activation of the HH pathway exist. First, the protein kinase A (PKA), the casein kinase 1α (CK1α) and GSK3β can phosphorylate and mark for proteosomal degradation the GLI transcription factors. [36] Second, Suppressor of Fused (SUFU) binds to GLI and

15777 records 552/1052 page Previous Next First page 上5页 551552553554555 下5页 Last page