• The subnuclear localizations of redox regulators is also lar

  2024-12-17

  

  The subnuclear localizations of redox regulators is also largely unknown. The potential role of thiol reductases as transcription regulators or DNA repair molecules may suggest an association to DNA. In this way, the presence of a zinc finger domain potentially involved in protein/DNA interactions o

• br Acknowledgments br Protein microarrays were developed to

  2024-12-17

  

  Acknowledgments Protein microarrays were developed to provide miniaturized high-throughput tools to study protein function, ML-098 sale and post-translational modifications. Just a few years ago, the seminal work performed in Stuart Schreiber's laboratory at Harvard University () and at Michael

• br Concluding Remarks and Future Perspectives Fluorescent

  2024-12-17

  

  Concluding Remarks and Future Perspectives Fluorescent γ-Linolenic Acid methyl ester synthesis have helped researchers to elucidate antibiotic MOA and off-target interactions, to screen for new antibiotics, to detect antibiotics in the environment, to track antibiotic uptake throughout cells and

• br Depletion of serum amino acids Currently the

  2024-12-17

  

  Depletion of serum amino acids Currently, the only anticancer agents that directly target amino label rna metabolism are bacterial l-asparaginases (from Escherichia coli and Erwinia chrysanthemi), which are FDA-approved for treatment of pediatric and adult ALL. A potential complication of using

• br Downstream signalling of AKT A consensus phosphorylation

  2024-12-17

  

  Downstream signalling of AKT A consensus phosphorylation motif has been described for AKT substrates: R-X-R-X-X-S/T-B where X represents any amino LY294002 and B represents bulky hydrophobic residues (Alessi, Caudwell, Andjelkovic, Hemmings, & Cohen, 1996). Numerous AKT substrates have been publi

• Gratifyingly compound also demonstrated improved physicochem

  2024-12-17

  

  Gratifyingly, compound also demonstrated improved physicochemical properties with significant improvement in aqueous solubility. Compound was sufficiently potent to determine its pharmacokinetic (PK) and pharmacodynamics (PD); data is summarized in . shows ADME characteristics for compound and

• As an alternative to chronic

  2024-12-17

  

  As an alternative to chronic receptor blockade, we have been targeting adenosine kinase (ADK) – an astrocyte-based enzyme that catalyses the phosphorylation of adenosine, as a means to modify xmu adenosinergic signalling (Boison, 2006, Etherington et al., 2009). Up-regulating ADK facilitates the cl

• br Introduction br Rac dependent ROS and

  2024-12-17

  

  Introduction Rac1-dependent ROS and WM-2474 synthesis regulation in neuronal functions NOX-mediated ROS have an important role as physiological messengers. One remarkable example regarding such a function is during axonal formation. In this line, increased p40phox/NOX2 levels and co-localizat

• To better understand the pathophysiology of ASDs we would ne

  2024-12-17

  

  To better understand the pathophysiology of ASDs, we would need comprehensive information on a) the functions of ASD-associated proteins in the brain, b) how mutations affect the expression level and function of these proteins, c) how mutations affect their function in neurons, and d) how changed ne

• br In patients with spina bifida and spinal

  2024-12-17

  

  In patients with spina bifida and spinal cord injury, fecal incontinence is a serious issue that can impair activities of daily living and patient self-esteem. To address this Malone et al. first described the Antegrade Continence Enema (ACE) procedure in 1990 [1], which achieves continence by all

• The srd a isoforms showed unique expression profiles in

  2024-12-17

  

  The srd5a isoforms showed unique expression profiles in early FHM development (Fig. 2). Similar to amphibian embryos, there was a high abundance of both srd5a1 and srd5a3 at 1dpf in FHMs, suggesting that mRNA for these enzymes may be maternally deposited and that these enzymes may play a key role in

• A promising target that is involved in the biosynthesis of

  2024-12-17

  

  A promising target that is involved in the biosynthesis of the precursor LTA4 is the 5-LO-activating protein (FLAP), which in vivo is seemingly indispensable for LT formation [8], [9]. FLAP, a member of the MAPEG family (membrane-associated proteins in eicosanoid and glutathione metabolism), is an i

• Introduction Cancer which is responsible for a

  2024-12-17

  

  Introduction Cancer, which is responsible for a million deaths each year, is universally feared, and approximately 50% of newly diagnosed cases can be cured [1]. The existing cancer treatments, including surgery, chemotherapy, radiotherapy or a combination of them, are quickly losing efficacy. The

• It has been shown that ACLY

  2024-12-16

  

  It has been shown that ACLY is localized to not only the cytoplasm but also the nucleus. Nuclear ACLY may supply acetyl-CoA for histone acetylation, leading to global regulation of the gene expression [16], [18]. We previously reported that AZ2 is also localized to both the cytoplasm and nucleus whe

• The analysis of the profile of protein phosphorylation in MM

  2024-12-16

  

  The analysis of the profile of protein phosphorylation in MMS-treated casein kinase 2 confirmed that both the ATM and ATR pathways were activated in S-phase blocked cells. Interestingly, phosphorylation of Chk1 was observed 24h after MMS-treatment both in AT- and ATM-inhibited cells, whilst in the

15590 records 4/1040 page Previous Next 12345 下5页 Last page